Immunology: An Infection Defense Game

Immunology: An Infection Defense Game

Genius Games · Board game · 2026
2–4 40–75 min
rating Ludopedia
rating BGG
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rating Ludopedia
rating BGG
Our Verdict
RECOMMENDED

Fans of cooperative games with unique themes will love this scientific dive into the immune system!

Highlights
  • Immersive thematic mechanics
  • Replayability with varied scenarios
  • Teaches science in a fun way
  • Good balance of luck and strategy
Keep in mind
  • May be complex for beginners
  • Games can run long with 4 players
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About the game

What you do in a play session

In Immunology, you and your friends become white blood cells in action! In this cooperative deck-building game, your team must defend a human body against dangerous bacteria like Streptococcus and Staphylococcus. Each player controls neutrophils and macrophages (the body's defense cells) that move across the board representing infected tissues. Cards allow you to attack invaders, generate resources to upgrade your deck, or produce reinforcements. But beware: if body temperature rises too high or tissues suffer excessive damage, it's game over! Scenarios vary with different pathogens and required strategies, ensuring high replayability. A immunology lesson disguised as a game - who said science can't be fun?

Best player count

BGG community vote

2–4 players
2 OK
3 OK
4 OK

Where to Buy

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Game details

Mechanics, categories, families and credits

Families

Admin: Upcoming Releases Theme: Bacteria Theme: Biology
Publisher Genius Games
Designer John Coveyou
Artist Tomasz Bogusz

Frequently Asked Questions

Quick answers before you buy

5 questions
How many players is it best with?
Works well with 2-4. With 4, games run longer but cooperation becomes richer.
Can it be played solo?
Yes! The cooperative mode allows controlling multiple characters alone, like in Pandemic.
Is the science theme heavy?
Not at all! Mechanics are intuitive and the rulebook explains biological concepts simply.
How does it differ from other deck-builders?
Here you build your deck DURING gameplay to respond to threats, like a real immune system!
Is there planned additional content?
Varied scenarios already ensure replayability, but the theme allows future expansions with new pathogens.